Effects of Dexmedetomidine on Agitation of Wilson's Disease Patients with Secondary Hypersplenism after General Anesthesia of Splonectomy / 中国药房
China Pharmacy
;
(12): 4513-4516, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-704449
ABSTRACT
OBJECTIVE:
To observe the effects of dexmedetomidine (Dex) on postoperative agitation of Wilson's disease patients with secondary hypersplenism after genernl anesthesia of splenectomy.METHODS:
A total of 60 Wilson's disease patients with secondary hypersplenism underwent general anesthesia of splenectomy duning Jan.-Dec.2016 were divided into control group and observation group according to random number table,with 30 cases in each group.Observation group was given intravenous pump of Dex 0.4 μg/kg at constant speed 15 min before anesthesia induction,and then maintained at 0.4 tg/(kg·h)till splenectomy completed.Control group was given constant volume of normal saline.Other anesthesia plans were same in 2 groups.Mean arterial pressure (MAP),heart rate (HR) and pulse oxygen saturation (SpO2) of 2 groups were observed before pumping (T0),before intubation (T1),1 min after intubation (T2),before extubation (T3),3 min after extubation (T4).Riker sedation-agitation score (SAS) were recorded in 2 groups at T3 and T4.The duration of stay in postanesthesia intensive care unit (PACU) and the occurrence of bradycardia were compared between 2 groups.RESULTS:
At T0,there was no statistical significance in MAP,HR or SpO2 levels between 2 groups (P>0.05).At T1,T2,T3 and T4,MAP and HR levels of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance (P<0.05).SpO2 were 100% at each time point,there was no statistical significance between 2 groups (P>0.05).Riker SAS scores of observation group was significantly lower than that of control group,with statistical significance (P<0.05).The incidence of bradycardia in observation group was 26.67%,which was significantly higher than 3.33% of control group,with statistical significance (P<0.05).But this symptom was corrected after intravenous injection of atropine.The duration of stay in PACU in observation group was significantly shorter than control group,with statistical significance (P<0.05).CONCLUSIONS:
Dex can keep postoperative hemodynamics stable in Wilson's disease patients with secondary hypersplenism,reduce agitation and shorten the time of the patients transferring from PACU.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2017
Tipo del documento:
Artículo
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