Effects of Trimetazidine on Myocardial Remodeling and Oxidative Stress in Patients with Hypertensive Heart Disease / 中国药房
China Pharmacy
;
(12): 89-93, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-704527
ABSTRACT
OBJECTIVE:
To prospectively study the effects of trimetazidine on myocardial remodeling and oxidative stress in patients with hypertensive heart disease (HHD),in order to provide reference for clinical treatment of HHD.METHODS:
Eighty-two HHD patients were selected from our hospital during Jan.2014-Jul.2016,and they were divided into control group and observation group by sortition randomization method,with 41 cases in each group.Control group received routine HHD chemical drug (antihypertensive drugs,lipid-lowering drugs,hypoglycemic agents and antiplatelet drugs,etc.) therapy.Observation group was additionally given trimetazidine 20 mg,tid,on the basis of control group.Both groups were treated for 3 months.Before treatment and after 3 months of treatment,SBP,DBP,New York Heart Association (NYHA) cardiac function grade,LVEF,LVESD,LVEDD,LVMI and the levels of GSH-Px,SOD,MDA and ROS were compared between 2 group.The occurrence of ADR was observed in 2 groups.RESULTS:
Before treatment,there was no statistical significance in each index between 2 groups (P>0.05).After 3 months of treatment,SBP and DBP of 2 groups were decreased significantly compared to before treatment (P<0.01);there was no statistical significance between 2 groups (P>0.05).There was no statistical significance in NYHA cardiac function grade compared to before treatment or between 2 groups (P>0.05).LVESD,LVEDD and LVMI of observation group were decreased significantly compared to before treatment (P<0.05);LVEF was increased significantly compared to before treatment (P<0.05);LVEDD and LVMI of observation group were significantly lower than control group (P<0.05).Compared to before treatment,SOD level of control group was decreased significantly,while the levels of GSH-Px and SOD in observation group were increased significantly;MDA and ROS of observation group were significantly lower than those of control group,with statistical significance (P<0.05).No obvious ADR was found in 2 groups.CONCLUSIONS:
Trimetazidine can improve cayocardial remodeling and reduce oxidative stress level of HHD patients with good safety.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Ensayo Clínico Controlado
Idioma:
Chino
Revista:
China Pharmacy
Año:
2018
Tipo del documento:
Artículo
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