Effects of Butylphthalide Combined with Alteplase on Neural Function and Cognitive Function and Serological Indexes as Hcy in Patients with Acute Cerebral Infarction / 中国药房

ABSTRACT

OBJECTIVE:To observe the effects of butylphthalide combined with alteplase on neural funetion and cognitive function and serological indexes as homocysteine(Hcy)in patients with acute cerebral infarction(ACI).METHODS:Clinical information of 78 ACI patients in emergency department of our hospital during Feb.2140-Apr.2017 were analyzed and then divided into control group and observation group according to therapy plan,with 39 cases in each group. Both groups received conventional treatment and Aspirin enteric-coated tablets orally. Control group was given Alteplase for injection 0.9 mg/kg for verous thromblysis on the basis of conventional treatment. Observation group was additionally given Butyphthalide soft capsules 0.2 g orally,tid,on the basis of control group. Both groups were treated for consecutive 28 days. The clinical efficacies of 2 groups were observed. NIHSS and MMSE scores before treatment,3,7,14 and 28 d after treatment,the levels of Hcy,NSE and 6-k-PGF1a were observed in 2 groups;the occurrence of ADR was recorded. RESULTS:After treatment,total response rate of observation group was 92.31%,which was significantly higher than 71.79% of control group,with statistical significance(P<0.05). 3-28 d after treatment,NIHSS scores of 2 groups were decreased gradually and significantly lower than before treatment;MMSE scores of 2 groups were increased gradually and significantly higher than before treatment,with statistical significance(P<0.05 or P<0.01). 7-28 d after treatment,NIHSS score of observation group was significantly lower than that of control group at same time,while MMSE score was significantly higher than control group, with statistical significance(P<0.05 or P<0.01). After treatment,serum levels of Hcy and NSE in 2 groups were decreased significantly,and observation group was significantly lower than control group;the level of 6-k-PGF1a was increased significantly,and observation group was significantly higher than control group,with statistical significance(P<0.05 or P<0.01). There was no statistical significantce in the total incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Butylphthalide combined with alteplase can significantly improve neurologic impairment and cognitive function of ACI patients,reduce serum levels of Hcy and NSE and increase the level of 6-k-PGF1a. Clinical efficacy of it is significantly better than alteplase alone.