Study on Quality Standard of Cnidium monnieri Liniment / 中国药房
China Pharmacy
;
(12): 1245-1248, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-704774
ABSTRACT
OBJECTIVE:
To formulate the quality standard of Cnidium monnieri liniment (called "liniment" for short)preliminarily.METHODS:
The property of liniment was observed. TLC was used for qualitative identification of osthole in liniment;relative density,alcohol content and pH value were also determined. The osthole and imperatorin in liniment were analyzed qualitatively by HPLC.RESULTS:
3 batch of samples were reddish brown liquid and fragrant smelling. In TLC of test sample,the same color fluorescent spots were found in corresponding position as chromatogram of control sample. The linear range of osthole and imperatorin were 0.101 2-0.910 8(r=0.999 6)and 0.006 2-0.124 4 mg/L(r=0.999 6). RSDs of precision tests were 1.38% and 0.79%(n=6). RSDs of stability tests were 0.33% and 0.41%(n=6). RSDs of reproducibility tests were 0.83% and 1.98%(n=6),respectively. Average recoveries rate were 98.73%(RSD=1.29%,n=6)and 99.25%(RSD=1.22%,n=6).Results of content determination showed that the content of osthole and imperatorin were 2.20-2.35 mg/mL and 0.310-0.340 mg/mL,respectively.CONCLUSIONS:
Established method is simple,rapid,accurate and can be used for quality control of C. monnieri liniment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Investigación cualitativa
Idioma:
Chino
Revista:
China Pharmacy
Año:
2018
Tipo del documento:
Artículo
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