Analysis of the Clinical Significance of Bone Morphogenetic Protein 2 in Glioblastoma Multiforme / 中国医科大学学报

ABSTRACT

Objective To investigate the prognostic significance of bone morphogenetic protein 2 (BMP2) expression in glioblastoma multiforme (GBM) and related pathways.Methods RNASeqV2 data and GSE7696 series matrix data were downloaded from The Cancer Genome Atlas (TCGA) and The Gene Expression Omnibus (GEO) database,respectively.The correlation between BMP2 expression and prognosis was evaluated using Kaplan-Meier and multivariate COX analysis.Gene set enrichment analysis (GSEA) was used to predict the functional gene sets and/or pathways modulated by BMP2.Results Decreased expression of BMP2 is an independent predictor of poor prognosis.Furthermore,genes that are upregulated in response to interferon-α proteins were enriched in samples with low BMP2 expression.Conclusion Low expression of BMP2 indicates poor prognosis in GBM patients.Genes that are upregulated in response to interferon-α proteins may also be implicated in prognosis.