Effect of Aidi injection on in vivo pharmacokinetics of doxorubicin in Sprague-Dawley rats by UPLC-MS method / 中国药理学通报

ABSTRACT

Aim To investigate the effect of Aidi injec-tion (ADI) on the pharmacokinetics of doxorubicin (DOX) and doxorubicinol (DOXol) in rats. In addi-tion, to explore the clinical significance of ADI and DOX combination. Methods SD rats were divided in-to single and combined administration groups. The combined group was injected with DOX(7 mg·kg-1) after intraperitoneally treated with ADI (10 mL· kg-1,once a day for continuous 14 d),while the sin-gle group was injected with DOX and saline. The con-centration of DOX in plasma was determined by UPLC-MS method,and then the difference in pharmacokinet-ic parameters were compared. Results The determi-nation methods with good precision and stability were suitable for the assay of DOX and DOXol in biological samples. The pharmacokinetic parameters of DOX and DOXol had no significant difference in two groups. Conclusion There is no obvious effect of ADI on the pharmacokinetics of DOX.