Oncometabolite 2-HG in glioma evolution and recent progress of detection method / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 898-902, 2018.
Article
en Zh
| WPRIM
| ID: wpr-705149
Biblioteca responsable:
WPRO
ABSTRACT
IDH mutation is prevalent in lower-grade glioma and secondary glioblastoma. Patients bearing IDH mutation are char-acterized by overproduction of 2-HG. 2-HG plays a role in regu-lation of DNA and histone hypermethylation in glioma, thus re-sulting in impaired cell differentiation and tumor formation. As a surrogate marker of mutant IDH, there is increasing interest in development of detection methods for 2-HG. LC-MS is widely used in detecting 2-HG in vitro, and reliable measurement of 2-HG by the non-invasive MRS has been tested in vivo and ex vivo previously. However, whether 2-HG could represent an inde-pendent predictor of patient survival or other clinical features for glioma still needs further study. In this review, we summarize the mechanism adopted by 2-HG in glioma initiation and pro-gression, as well as the detection method tested in clinic. We try to provide guidance to the future combination therapy using mu-tant IDH inhibitors.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Diagnostic_studies
/
Guideline
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Año:
2018
Tipo del documento:
Article