Research advances in drug-induced mitochondrial toxicity / 中国药理学与毒理学杂志

ABSTRACT

Mitochondria perform important functions in energy production, balancing redox reac-tions, maintaining homeostasis, cell proliferation and apoptosis. Mitochondrial function is essential for human health.This is evidenced by a large number of diseases caused by mutations in the mitochon-drial genome and the key role of mitochondrial dysfunction in many chronic diseases.A number of commonly used drugs can impair mitochondrial function,leading to adverse reactions or toxicity.Drug-induced mito-chondrial dysfunction includes mitochondrial DNA damage, impaired mitochondrial respiration, increased production of reactive oxygen species and altered mitochondrial permeability. Based on data from experimental and clinical research, this review focuses on toxicity and mechanisms of common drugs such as analgesics,anticancer drugs and hypolipidemic drugs on mitochondria in order to provide guid-ance for clinical medication safety and new thoughts for analysis and screening of drug-induced mito-chondrial toxicity.