Role of autophagy in doxorubicin-induced cardiotoxicity:review / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 923-926, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-705215
ABSTRACT
Doxorubicin (Dox) is an effective wide-spectrum antitumor drug. However, its clinical application may be hampered by dose-dependent cardiotoxicity. The mechanisms of cardiotoxicity have not been clearly elucidated, but are known to involve oxidative stress, mitochondrial dysfunction and apoptosis. Autophagy is a lysosome-dependent protein degradation pathway. More recently, many studies have suggested that autophagy plays an important role in Dox-induced cardiotoxicity. This paper gives a systematic review of the role of autophagy in Dox-induced cardiotoxicity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2017
Tipo del documento:
Artículo
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