Literature Analysis on Administration Sequence and Antibacterial Efficacy in the Combination Use of Am-broxol and Antibacterial Agents / 中国药师

ABSTRACT

This article reviewed the pharmacokinetic and pharmacodynamic characteristics of ambroxol and the interactions be-tween ambroxol and antibacterial agents. The use order of ambroxol and antiseptic drugs was analyzed and discussed. Ambroxol was a-ble to increase antibiotics concentration in bronchoalveolar lavage fluid (BALF) samples. Besides, ambroxol could destroy the struc-ture of bacterial biofilm(BF) in a dose-dependent manner,and high dose of ambroxol hydrochloride showed good safety. When ambr-oxol and antibacterial agents were in combination use,ambroxol should be administrated before antibacterial agents in order to enhance antibacterial efficacy,since ambroxol could increase the concentration of antibacterial agents in lung and help the antibacterial agents enter the bacterial BF. It was suggested that the label of ambroxol be further improved and revised as follows①the administration se-quence of ambroxol and antibacterial agents should be stated;②the recommended doses of ambroxol for different indications should al-so be listed in the label;③ the clinical safety and efficacy of high dose of ambroxol should be stated.