Antipyretic, Anti-inflammatory and Analgesic Effects of Yinhaojiere Mixture and Antipyretic Effect of Ilex Asprella / 中国药师

ABSTRACT

Objective: To study the antipyretic, anti-inflammatory and analgesic effects of Yinhaojiere mixture and the antipyretic effect of Ilex asprella. Methods: The experiments of mice ear edma induced by xylene, the increase of capillary permeability by acetic acid and the sterilized cotton caused rat groin granulation tissue hyperplasia were used to study the anti-inflammatory effect of Yinhao-jiere mixture; the hot-plate tests and the acetic acid writhing test were applied to research the analgesic effect of Yinhaojiere mixture. In addition, the dry yeast induced fever in rats was employed to explore the efficacy of antipyretic agents in Yinhaojiere mixture and Ilex asprella water extract. Results: Yinhaojiere mixture could obviously inhibit the inflammation of the peritoneal cavity of mice ( P <0. 05). The inhibition of Yinhaojiere mixture against ear swelling induced by p-xylene was significant. Yinhaojiere mixture could sig-nificantly increase the pain threshold. Especially, Yinhaojiere mixture had significant antipyretic effect (P<0. 05). In the anti-inflam-matory, analgesic and antipyretic experimetns, there were no significant differences between the middle and high dose groups of Yinha-ojiere mixture and indomethacin group (P>0. 05). Conclusion: Yinhaojiere mixture with the Ilex asprella as the main ingredient has notable anti-inflammatory, analgesic and antipyretic effects, and Ilex asprella exhibits anti-inflammatory, analgesic effects, and its anti-pyretic effect is more significant.