Effect of Genetic Polymorphism in CYP2C9 and VKORC1 on Warfarin Used in Pregnant Patients with Mechanical Valve Replacement / 中国药师
China Pharmacist
; (12): 1790-1793, 2018.
Article
en Zh
| WPRIM
| ID: wpr-705707
Biblioteca responsable:
WPRO
ABSTRACT
Objective: To explore the effects of genetic factors and non-genetic factors on warfarin dosage in pregnant women after heart valve replacement. Methods: Totally 68 pregnant women were treated with warfarin throughout pregnancy. PCR-chip method was used to detect the polymorphism of CYP2C9 and VKORC1 gene,and the clinical data were collected. The effects of genetic factors and non-genetic factors on stable dosage of warfarin were statistically analyzed. Results: CYP2C9, VKORCl genotypes and weight had sig-nificant effects on warfarin dosage. The three variables could explain 44. 6% of warfarin individual differences. Conclusion: Genetic factors have significant effect on warfarin dosage in pregnant patients, so the detection of genetic polymorphism of CYP2C9 and VKORCl can be applied to individualize warfarin dosage in pregnant patients with heart valve replacement.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Año:
2018
Tipo del documento:
Article