Research developments on obesity-related inflammation / 中国医师杂志

ABSTRACT

Obesity,a risk factor for type 2 diabetes mellitus (T2DM),hypertension,cardiovascular diseases and cancers et al,has become a major global health problem.Multiple fundamental studies have revealed that obese subject is under a status of low-grade,chronic inflammation,which contributes to the development of insulin resistance and T2DM.Thus,anti-inflammatory treatment of T2DM has been greatly developed.Yet,so far,the effectiveness of anti-inflammatory therapy is controversial,which implies that the researchers need to re-examine the association between inflammation,insulin resistance and T2DM.In this reviews,we will focus on the relationships between obese-associated inflammation and insulin resistance and the trigger mechanism of this inflammation.