Application of next-generation sequencing in children with unexplained neurodevelopmental disorders / 中国医师杂志

ABSTRACT

Neurodevelopmental disorders are diseases affecting language,sports,intelligence and social adaptability,and through appropriate early intervention,part of the affected children can recover to the same or similar level as normal children,so it is of vital importance to provide accurate early identification and comprehensive intervention for the affected children.Now the gene technology is applied widely,especially the next-generation sequencing is characterized by high throughput,low cost and fast sequencing,which has made great progress in assisting the diagnosis of children with unexplained neurodevelopmental disorders.Therefore,genetic diagnosis can be used to understand the prognosis of children and to provide genetic counseling for their parents,which is conductive to reducing their incidence and early intervention.