Research progresses of resting-state functional MRI in patients of end-stage renal disease patients with cognitive impairment / 中国医学影像技术

ABSTRACT

End-stage renal disease (ESRD) is often complicated with damage of multi-organ function,among them,cognitive impairment has been noticed with a high prevalence.The abnormal intrinsic brain activity patterns in resting state is one of the manifestations of cognitive impairment in ESRD.Resting-state functional MRI (rs-fMRI) is divided into two categories,i.e.functional separation and functional integration,reflecting the changes of neural activity of the brain in different aspects.With advantages of non-invasive,no radiation and high spatio-temporal resolution,rs-fMRI has gradually become an effective method in studying the neurophysiological mechanisms of cognitive impairment.The pathophysiology and research progresses of rs-fMRI in ESRD with cognitive impairment were reviewed in this article.