Dynamic Contrast-enhanced Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Differential Diagnosis of Osteosarcoma / 中国医学影像学杂志

ABSTRACT

Purpose To explore the dynamic contrast-enhanced (DCE) MRI curve type and hydrogen proton magnetic resonance spectroscopy (1H-MRS) in the diagnosis of primary osteosarcoma.Materials and Mothods This was a prospective study.Dynamic contrast enhancement and 1H-MRS scanning wcre performed in forty-one osteosarcoma patients who were eligible for the study.According to the pathological findings,patients were divided into high malignant osteosarcoma group and low malignant osteosarcoma group.The time-signal intensity curves (TIC) were obtained and classified by the analysis software.Among them,18 patients with stable 1H-MRS spectrum were analyzed,and Cho as well as Cho/Cr value was obtained and statistically analyzed,respectively.Results The type Ⅰ and type Ⅱ TIC curves in high malignant osteosarcoma group were 20 and 10 cases,respectively.The type Ⅰ,type Ⅱ and type Ⅲ TIC curves in low malignant osteosarcoma group were 2,5 and 4 cases,respectively.The difference of TIC type distribution between high and low malignant osteosarcoma was statistically significant (x2=10.876,P＜0.05).The difference of Cho/Cr value between high and low malignant osteosarcoma was statistically significant (Z=-2.445,P＜0.05).Consider Cho/Cr value as the diagnostic index,the best cut-off value was 2.3.Conclusion TIC type and Cho/Cr value have certain reference value for evaluating the malignant degree of osteosarcoma.