Correlations of bcl-2 expression with clinicopathological features in breast cancer
Yonsei Medical Journal
;
: 206-211, 1997.
Artículo
en Inglés
| WPRIM
| ID: wpr-70663
ABSTRACT
To evaluate the prognostic significance of bcl-2, we investigated the correlation of bcl-2 expression with the established indicators of prognosis and tumor behavior in breast cancer. This study included a patient group of 91 histologically diagnosed female breast carcinomas. To determine the bcl-2 immunoreactivity, we used a monoclonal antibody directed against the bcl-2 protein by immunohistochemistry from paraffin-embedded tissue in a series of 91 women with breast cancer. Interpretable DNA histograms were obtained from 84 patients. The median age at diagnosis was 45.5 years and the median follow-up time was 30.5 months. Forty-eight (52.7%) cancers showed the bcl-2 immunoreactivity in the cytoplasm. The nonneoplastic portion of ductal epithelial cells and normal lymphocytes were usually stained with bcl-2 antibody. Estrogen receptors (ER)(p 0.05) and DNA ploidy (p > 0.05) were not related with it. The bcl-2 positive patients showed longer survival (p 0.05), nuclear grade (p > 0.05), ER status (p > 0.1) and PR status(p > 0.1) were not reliable indicators for overall survival except histologic grade (p < 0.05). Our results suggest that bcl-2 expression may be related to hormonal regulation and tumor differentiation in breast carcinoma. Larger patient study groups with a longer follow-up period will be helpful to clarify the prognostic significance of bcl-2.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Mama
/
Carcinoma in Situ
/
Receptores de Progesterona
/
Receptores de Estrógenos
/
Carcinoma Ductal de Mama
/
Proteínas Proto-Oncogénicas c-bcl-2
/
Persona de Mediana Edad
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
1997
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS