Research progress on mechanism of long non-coding HOTTIP RNA in regulating diges-tive system carcinomas / 中国肿瘤临床

ABSTRACT

HOTTIP RNA is a type of long non-coding RNA, which is transcribed from the HOXA gene at its distal tip and coordinates the activation of 5'HOXA genes. Particularly, it regulates the expression of the neighboring HOXA 13 gene. Recently, emerging lines of evi-dence have suggested that increased expression of HOTTIP is observed in digestive system carcinomas, including esophageal cancer, gastric cancer, hepatocellular carcinomas, pancreatic cancer, and colorectal cancer, and is closely associated with the initiation and pro-gression of cancer, and affects the survival and prognosis of cancer patients. Therefore, it is expected to be a diagnosis index marker, prognosis indicator, and a new therapeutic target for the relevant tumors. Here, we focus on the discovery of lncRNA HOTTIP, its mech-anism, and the latest developments in the research on HOTTIP in digestive system carcinomas.