Advances in targeted therapy of gastric cancer / 中国肿瘤临床

ABSTRACT

Progress in the treatment of gastric cancer(GC)is a major concern because GC is a common cancer worldwide.Recently,by studying the molecular mechanisms of GC,researchers learned that GC progression involved a series of changes at the molecular lev-el,including the activation of signaling pathways,abnormal expression and mutation of genes,and response to related targeted drugs used in clinics.However,many targeted drugs produce resistance in a short period of time because of complicated cellular,microenvi-ronmental,and genetic instabilities.Therefore,it is important to find new targets against GC.In this review,we present the current re-search status and progress with respect to GC targets.