Research progress of histone H3.3 G34R/V mutation in neuroglioma / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 595-598, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-706855
ABSTRACT
There are two genes encoding H3F3A and H3F3B in human histone H3.3 variant. The mutation rate of G34R/V is lower than that of K27M in high-grade glioma. H3.3 G34 mutation presents a histopathologically heterogeneous, with microscopic characteristics of typical glioblastoma (GBM), central nervous system primitive neuroectodermal tumors (CNS-PNET), or even astroblastoma. More-over, G34-mutant tumor has its unique manifestation in the age of onset, tumor location, and prognosis. CNS tumors with H3.3 G34 mutations displayed uniform epigenetic signatures, suggesting a single biological origin. Chromosome 3q and 4q deletions were more common and specific in G34-mutant tumors, which were often accompanied by PDGFRA or CCND2 amplification, than in other sub-types of GBM. Here, we review the clinicopathological and molecular genetic characteristics of histone H3.3 G34R/V mutant gliomas.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Clinical Oncology
Año:
2018
Tipo del documento:
Artículo
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