Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis
Journal of Korean Medical Science
; : 950-956, 2014.
Article
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| WPRIM
| ID: wpr-70751
Biblioteca responsable:
WPRO
ABSTRACT
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9+/-149.7 microL vs. 192.5+/-127.7 microL, P=0.001, and 32.7+/-26.8 microL vs. 22.8+/-19.4 microL, P=0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P=0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P=0.050) and NLR>2.73 (OR, 1.848; 95% CI, 1.016-3.360, P=0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P=0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR.
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Índice:
WPRIM
Asunto principal:
Pacientes
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Enfermedad de la Arteria Coronaria
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Proteína C-Reactiva
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Linfocitos
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Oportunidad Relativa
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Estudios Retrospectivos
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Angiografía Coronaria
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Ultrasonografía Intervencional
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Placa Aterosclerótica
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Hospitales Universitarios
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2014
Tipo del documento:
Article