Evaluation of left ventricular systolic function and synchronicity in patients with maintenance hemodialysis by layer-specific strain / 中华超声影像学杂志

ABSTRACT

Objective To explore the systolic function and synchronicity of left ventricle ( LV ) in patients with maintenance hemodialysis( MHD) by layer-specific strain. Methods Forty-three patients with MHD and 48 healthy controls were studied. Three consecutive cardiac cycles two-dimensional dynamic images including standard LV apical two-chamber,long-axis and four-chamber views and LV short-axis views at the levels of basal,middle and apical were acquired. A quantitative software called EchoPAC was used to analyze longitudinal strain(LS) and circumferential strain(CS) of these six dynamic images and peak strain dispersion ( PSD) was automatic computed by the software. The difference of these parameters between the two groups and the correlation between PSD and other parameters were studied. Results Parameters of global layer-specific strain: compared with the control group, global LS and CS of subendocardial,midmyocardial,epicardial and full-thickness myocardium layers were decreased in the MHD group ( P ＜0.01). Parameters of segmental layer-specific strain:LS of 3 layers and full-thickness in basal, middle,apical segments were lower in MHD group than those in control group ( P ＜0.001). CS of 3 layers and full-thickness in middle,apical segments were lower in MHD group than those in control group ( P ＜0.05). There was no significant difference in CS of 3 layers and full-thickness in basal segment between two groups( P ＞0.05). Parameters of synchronicity:PSD of MHD group was larger than that of control group ( t ＝6.094, P ＜0.001). PSD was positively correlated with longitudinal strain of full-thickness (GLS) in MHD group ( rs＝0.478, P ＝0.039). Conclusions Layer-specific strain can noninvasively and accurately quantitate left ventricular systolic function and synchronicity in patients with MHD.