Follow-up of radiosensitive tissues in children with congenital heart disease treated by interventional operation / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
;
(12): 37-42, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-708010
ABSTRACT
Objective To understand effects of the interventional operation on thyroid,peripheral blood indexes and chromosomal aberrations (CA) of peripheral lymphocyte of children with congenital heart disease (CHD).Methods Follow-up studies were conducted in 70 child patients undergoing cardiac catheterization and 23 with open heart surgery as control from 2010 to 2013.Postoperative follow-up examinations included thyroid ultrasound,blood routine indexes and analyses of CAs.Results Difference in thyroid ultrasound abnormality rate was not statistically significant between children with cardiac catheterization and control group (40.0% vs.43.5%,P > 0.05).There was no significant difference in white blood cell (WBC) count between interventional group and control group (P > 0.05).The effects of disease type and operation time on thyroid ultrasound and WBC count were not observed (P > 0.05).The frequency of chromosome aberrations,including acentric fragment,dicentrics and translocation in interventional group [(0.76 ± 0.07) %],was higher than in control group [(0.25 ± 0.07) %,(Z =-3.631,P < 0.05],and the rates of acentric fragment and translocation were also higher in interventional group (Z =-2.531,-2.397,P < 0.05).Conclusions Effect of intervention therapy on thyroid structure and WBC count in children with CHD was not observed,but the genotoxic effects remain in children with cardiac catheterization.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Radiological Medicine and Protection
Año:
2018
Tipo del documento:
Artículo
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