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Roles of exosomes in the diagnosis and treatment of patients with pancreatic cancer / 中华肝胆外科杂志
Chinese Journal of Hepatobiliary Surgery ; (12): 64-67, 2018.
Artículo en Chino | WPRIM | ID: wpr-708358
ABSTRACT
Exosomes are small membrane bound vesicles typically 30 ~ 150 nm in size which are widely distributed in the body fluids.The cytosol is rich in proteins and nucleic acids which mediates communication between different cells and transporting substances.Exosomes are involved in pancreatic cancer initiation and progression by promoting the formation of tumor microenvironment,enhancing gemcitabine resistance.GPC1 + circulating exosomes and high exosome levels of microRNA-10b serve as potertial non-invasive diagnostic tools to detect pancreatic cancer in the early stage.Meanwhile,exosomes could successfully deliver genetic drugs,anticancer drugs to target cells.In this article,we provide a review on the recent advances on exosomes in the diagnosis and treatment of pancreatic cancer.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico Idioma: Chino Revista: Chinese Journal of Hepatobiliary Surgery Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico Idioma: Chino Revista: Chinese Journal of Hepatobiliary Surgery Año: 2018 Tipo del documento: Artículo