Factors influencing long-term survival after hepatectomy in patients with a single large hepatocellular carcinoma / 中华肝胆外科杂志

ABSTRACT

Objective To study the prognostic factors which affected the long-term survival in patients with a single large hepatocellular carcinoma (SLHCC) after hepatectomy.Methods The clinical data of 138 SLHCC patients who underwent hepatectomy in the Tianjin Hospital from January 2008 to December 2013 were retrospectively analyzed.There were 115 males and 23 females.Age ranged from 23 to 81 years (median 56.8 years).The impact of an array of clinicopathological factors was analyzed using a variety of statistical methods which included the Kaplan-Meier estimator and the Log-rank test.Results The 1,3,5 year overall survival rates for all the patients were 86.4％,64.8％ and 54.1％,respectively,and the 1,3,5 year disease free survival rates were 68.8％,41.4％ and 33.2％,respectively.Univariate analysis indicated that microvascular invasion,preoperative AFP≥400 μg/L,a maximum tumor diameter ≥ 10 cm,and preoperative AST ≥40 U/L were risk factors of overall survival (all P ＜ 0.05),and microvascular invasion,preoperative AFP≥400 μg/L,and preoperative AST ≥40 U/L were risk factors of disease free survival (all P ＜ 0.05).Multivariate analysis showed that microvascular invasion,preoperative AFP ≥400 μg/L and preoperative AST ≥40 U/L were independent prognostic factors of overall survival and disease free survival for these patients (all P ＜ 0.05).Conclusion Microvascular invasion,preoperative AFP ≥400 μg/L and AST ≥40 U/L were independent prognostic factors of long survival of SLHCC patients.