Targeted imaging and therapy of prostate cancer by radionuclide labeled small molecule inhibitors of prostate specific membrane antigen / 中华核医学与分子影像杂志

ABSTRACT

Prostate specific membrane antigen (PSMA) overexpresses in most prostate cancer (PCa) lesions and plays an important role in the early diagnosis and preoperative staging,clinical decision making,recurrence and metastasis detection as well as targeted therapy.Radionuclide (especially 68Ga and 177Lu) labeled multiple small molecule inhibitors of PSMA have been wildly used in SPECT,PET imaging on PCa,and play an important role in the treatment of metastatic castration resistant prostate cancer (mCRPC).This review summarizes the development in these fields.