Relationship of between carotid atherosclerosis and serum markers in elderly essential hypertension patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship between carotid atherosclerosis (CAS) and serum markers in elderly essential hypertension (EH) patients.Methods Three hundred and eightyeight elderly EH patients who underwent carotid colour ultrasonography and biochemical testing served as an EH group and 82 subjects undergoing physical examination served as a control group.The patients in EH group were divided into plaque-free group (n =142),stable plaque group (n=132),and unstable plaque group (n=114).The relationship between CAS and serum FPG,Hcy,TBIL,DBIL,IBIL,UA,ferritin,fibrinogen,CRP levels was analyzed.Results The incidence of CAS and serum Hcy level were significantly higher in EH group than in control group (63.40％ vs 31.71％,12.69±3.58 μmol/L vs 6.96±2.89 μmol/L,P＜0.01).The incidence of CAS was 63.40％ in EH patients.The serum levels of FPG,TC,TG,LDL-C,Hcy,UA,ferritin,fibrinogen,CRP were significantly higher while those of TBIL,DBIL,and IBIL were significantly lower in stable plaque group than in unstable plaque group (P＜0.05,P＜0.01).Logistic regression analysis showed that stable CAS was negatively related with serum levels of TBIL and IBIL and positively related with those of FPG,TC,LDL-C,Hcy,UA,ferritin,fibrinogen and CRP,history of smoking,incidence of DM and hypertension (P＜0.05).Conclusion Serum levels of TBIL and IBIL are the protective factor for CAS while those of FPG,Hcy,UA,ferritin,fibrinogen and CRP are the risk factors for CAS in elderly EH patients.