Effect of telmisartan taken at different times on non-dipper and morning hypertension / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the effect of telmisartan taken at different times on 24 h ambulatoryblood pressure monitoring (ABPM) parameters and vascular endothelium functionin in patients with non-dipper and morning hypertension.Methods Eighty mild-moderate essential hypertension (EH) patients admitted to the Affiliated Hospital of Guizhou Medical University from September 2014 to December 2015 were randomly divided into morning drug taking group (n=40) and evening drug taking group (n=40).The patients in morning drug taking group took 80 mg telmisartan at h 7-9 in the morning and those in evening drug taking group took 80 mg telmisartan at h 19-21 in the evening for 12 weeks.Their ABPM parameters were recorded,their blood pressure and serum levels of von Willebrand factor (vWF) and hs-CRP were measured after treatment.Results The mean night and morning SBP and DBP were significantly lower in evening drug taking group than in morning drug taking group (P＜0.05).The serum levels of vWF and hs-CRP were significantly lower in evening drug taking group than in morning drug taking group (148.3％±11.4％ vs 162.4％ ± 12.1％,2.9±0.5 mg/L vs 3.6±0.6 mg/L,P＜0.05).Conclusion Telmisartan taken in the evening can reduce the night and morning blood pressure,serum vWF and hs-CRP levels,and improve the vascular endothelium function in patients with non-dipper and morning hypertension.