Relationship between fibroblast growth factor 21 and blood glucose after cardiac surgical operation / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship between fibroblast growth factor 21 (FGF21) and blood glucose (BG) after cardiac surgical operation.Methods Eighty-six coronary atherosclerotic heart disease patients without DM were divided into postoperative normal BG group (n=46) and postoperative elevated BG group (n =40).Their preoperative baseline data were recorded,their plasma FGF21 level was measured before and after operation.The relationship between FGF21 and BG was analyzed by dual regression analysis.Results The serum FGF21 level was signifycantly higher in two groups after operation than before operation (7.49±0.53 μg/L vs 3.04±0.26 μg/L,P＜0.01) and in postoperative normal BG group than in postoperative elevated BG group (5.84±0.72 μg/L vs 2.84±0.46 μg/L,P＜0.01).The circulating FGF21 level was related with the postoperative elevated BG level (OR =10.67,95％CI2.34-48.63,P＜0.01).Conclusion BG is closely related with FGF21 after coronary bypass,which is of great importance for the management of BG after cardiac surgical operation.