New advances in pheochromocytoma and paraganglioma--the 5th international symposium on pheochromocytoma and paraganglioma / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 532-536, 2018.
Artículo
en Chino
| WPRIM
| ID: wpr-709977
ABSTRACT
The 5th international symposium of pheochromocytoma and paraganglioma ( PPGL) has been held in September 2017 in Sydney. The conference included the new advances and progresses in the pathogenesis, diagnosis, and treatment of the PPGL. Comprehensive molecular characterization revealed that 95% of PPGL had single or combined germline mutations ( 27%), somatic mutations ( 39%), fusion gene ( 7%) or copy number alterations ( 89%). PPGL could be divided into kinase signaling subtype, pseudohypoxia subtype, Wnt-altered subtype and cortical admixture subtype. The sensitivity of 68Ga-dotatate-positron emission tomography/computed tomography (PET/CT) to detect the PPGL was quite high, which provided a basis for the treatment of PPGL by 177Lu-dota. The treatment of malignant PPGL included tyrosine kinase inhibitors, 131I-metaiodobenzylguanidine (MIBG ), and pembrolizumab. The ultratrace 131I-MIBG, was quite effective for the treatment of malignant PPGL. Although PPGL is a rare and complicated disease, multidisciplinary team and further research will bring more benefits to the early detection and appropriate treatment of PPGL patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio de tamizaje
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2018
Tipo del documento:
Artículo
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