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Effects of three preparation technologies on the oral bioavailability of berberine α-hydroxy β-decanoylethyl sulfonate / 中成药
Article en Zh | WPRIM | ID: wpr-710185
Biblioteca responsable: WPRO
ABSTRACT
AIM To compare the effects of three preparation technologies on the oral bioavailability of HB (berberine α-hydroxy β-decanoylethyl sulfonate,houttuyn berberine).METHODS Solid dispersions,HP-β-CD inclusion complexes and nanosuspension freeze-dried powders were prepared.The suspensions of crude drug and these three preparations were intragastrically administered to SD rats,respectively.HPLC-MS/MS was adopted in the content determination of HB in plasma.then pharmacokinetics parameters were calculated.RESULTS Compared with the crude drug,three preparation technologies could significantly increase the Cmax value of this component (P < 0.05),especially for HP-β-CD inclusion complexes (P < 0.01).And HP-β-CD inclusion complexes demonstrated much higher AUC0-6h than the crude drug and the other two preparation technologies (P < 0.05).CONCLUSION HP-β-CD inclusion complexes can effectively increase the oral bioavailability of HB.
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Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Traditional Patent Medicine Año: 2018 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Chinese Traditional Patent Medicine Año: 2018 Tipo del documento: Article