The influence of hypochromic anemia on HbA1cin the pregnant women / 中华检验医学杂志

ABSTRACT

Objective To explore the effects of the low pigmented anemia on glycated hemoglobin of pregnant women with normal glucose metabolism.Methods The study retrospectively selected the 10-28 weeks pregnant women of 647 cases(292 cases with Hb≥110 g/L and 355 cases with Hb<110 g/L)with normal fasting blood glucose at the Qingpu Branch of Zhongshan Hospital, Fudan University, between January and June 2017.According to their MCH and MCV,patients were divided into two groups.There are observation group which including 89 cases with MCH<27 pg and MCV<82 fl and 196 cases with MCH<27 pg and MCV≥82 fl as(low pigment group)and 362 cases with MCH≥27 pg and MCV≥82 fl as control group which including 70 cases with Hb≥110 g/L and 292 cases with Hb <110 g/L.RBC parameters, fasting plasma glucose and glycosylated hemoglobin of all cases were detected on the Hitachi 7600 automatic biochemical analyzer and HLC-723G8 automatic glycosylated hemoglobin analyzer.The t test, chi-square test and Bonferroni test were used for statistical analysis.Results Statistical analysis showed the fasting blood glucose of the pregnant women without anemia(Hb≥110 g/L)and the pregnant women with anemia (Hb<110 g/L)were(4.68 ±0.36)mmol/L and(4.632 ±0.33)mmol/L respectively, and there is no statistical difference between them with t=-1.860,P=0.063.The and glycosylated hemoglobin levels of the pregnant women with Hb≥110 g/L and the pregnant women with Hb <110 g/L were(4.851 ±0.32)%and(4.872 ±0.35)%respectively,and there is no statistical difference between them with t=0.780,P=0.436.The fasting blood glucose of the cases with MCH <27 pg and MCV<82 fl,the cases with MCH<27 pg and MCV≥82 fl and the cases with MCH≥27 pg and MCV≥82 fl were(4.609 ±0.319)mmol/L, (4.586 ±0.381)mmol/L,(4.661 ±0.344)mmol/L respectively, and there was no statistical difference among them with F=1.105,P=0.332;the glycated hemoglobin levels of the three groups were(5.097 ± 0.409)%,(5.084 ±0.375)% and(4.835 ±0.321)% respectively, the glycated hemoglobin of the cases with MCH<27 pg were statistically higher than that of the cases with MCH≥27 pg with F=18.479,P<0.000 1 and absolute difference was 0.26%.Conclusion Low pigment anemia with MCH <27 pg has a significant effect on glycated hemoglobin levels in pregnant women,which can cause the increase of glycated hemoglobin in pregnant women.