Progress of autotaxin in tumors / 肿瘤研究与临床

ABSTRACT

Autotaxin (ATX) as a member of nucleotide pyrophosphatase/phosphodiesterase (ENPP) family, possesses the activity of lysophospholipase D, and plays a key role in lipid signaling pathway.Increased ATX expression has been detected in a large variety of cancers,implying its important functions in tumor origination and development, especially tumor metastasis. Moreover, ATX has been shown to contribute to drug resistance and angiogenesis. ATX emerges as an attractive target in tumor biology due to its multiple activities in tumor biology.This review summarizes the current progress of ATX in tumors.