Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
Biomolecules & Therapeutics
;
: 115-120, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-713585
ABSTRACT
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect of duloxetine (DXT), a potent and balanced serotonin/norepinephrine reuptake inhibitor, on CCH-induced neuronal damage in the hippocampal CA1 region using a rat model of permanent bilateral common carotid arteries occlusion. We found that treatment with 20 mg/kg DXT could attenuate the neuronal damage, the reduction of phosphorylations of mTOR and p70S6K as well as the elevations of TNF-α and IL-1β levels in the hippocampal CA1 region at 28 days following CCH. These results indicate that DXT displays the neuroprotective effect against CCH-induced hippocampal neuronal death, and that neuroprotective effect of DXT may be closely related with the attenuations of CCH-induced decrease of mTOR/p70S6K signaling pathway as well as CCH-induced neuroinflammatory process.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fosforilación
/
Encéfalo
/
Demencia Vascular
/
Arteria Carótida Común
/
Trastornos del Conocimiento
/
Fármacos Neuroprotectores
/
Modelos Animales
/
Proteínas Quinasas S6 Ribosómicas 70-kDa
/
Región CA1 Hipocampal
/
Clorhidrato de Duloxetina
Idioma:
Inglés
Revista:
Biomolecules & Therapeutics
Año:
2018
Tipo del documento:
Artículo
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