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Differential Association of Vitamin D Deficiency With Albuminuria by Sex in the Korean General Population: A Cross-sectional Study of the Korea National Health and Nutrition Examination Survey 2011-2012 / 예방의학회지
Journal of Preventive Medicine and Public Health ; : 92-99, 2018.
Artículo en Inglés | WPRIM | ID: wpr-713648
ABSTRACT

OBJECTIVES:

Albuminuria has emerged as a biomarker for several medical conditions, and vitamin D has received attention due to its associations with various disorders. We evaluated the association between low serum vitamin D levels and prevalent albuminuria by sex in the Korean general population.

METHODS:

We analyzed 9823 participants (4401 males, 5422 females) from the Korea National Health and Nutrition Examination Survey 2011-2012 (KNHANES V-2), and categorized them as having a normal range of vitamin D levels, vitamin D insufficiency, or vitamin D deficiency. A multivariable logistic regression model was used to compare the risk of albuminuria across these groups. Stratified analyses were conducted by smoking status, obesity, and renal function.

RESULTS:

Albuminuria was found in 325 of the 4401 male participants (7.4%) and in 455 of the 5422 female participants (8.4%). Among the males, vitamin D deficiency was associated with an odds ratio (OR) for albuminuria of 1.78 (95% confidence interval [CI], 1.07 to 2.97, p < 0.05). However, such an association was not found in females. The association was stronger in male current smokers (OR, 3.54; 95% CI, 1.47 to 8.50; p=0.005).

CONCLUSIONS:

The findings of this study suggest that sex differences exist in the association between serum vitamin D deficiency and albuminuria. Additionally, we observed that the association was stronger in current smokers than in the overall male population, but was not seen in non-smokers. Therefore, different approaches by sex and smoking status might be needed when considering using vitamin D as a biomarker for renal function.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Valores de Referencia / Humo / Vitamina D / Deficiencia de Vitamina D / Vitaminas / Fumar / Modelos Logísticos / Oportunidad Relativa / Factores Sexuales / Encuestas Nutricionales Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Preventive Medicine and Public Health Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Valores de Referencia / Humo / Vitamina D / Deficiencia de Vitamina D / Vitaminas / Fumar / Modelos Logísticos / Oportunidad Relativa / Factores Sexuales / Encuestas Nutricionales Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Preventive Medicine and Public Health Año: 2018 Tipo del documento: Artículo