Successful Treatment of Cisplatin Overdose with Plasma Exchange
Yonsei Medical Journal
; : 128-132, 2002.
Article
en En
| WPRIM
| ID: wpr-71367
Biblioteca responsable:
WPRO
ABSTRACT
We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m2 of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
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Asunto principal:
Intercambio Plasmático
/
Cisplatino
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Sobredosis de Droga
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Persona de Mediana Edad
/
Antineoplásicos
Límite:
Humans
/
Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2002
Tipo del documento:
Article