Long-Term Effects of Helicobacter pylori Eradication on Metachronous Gastric Cancer Development
Gut and Liver
;
: 133-141, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-713723
ABSTRACT
BACKGROUND/AIMS:
Gastric mucosal atrophy and intestinal metaplasia due to Helicobacter pylori infection are the main precursor lesions of gastric cancer. The aim of this study was to evaluate the long-term effects of H. pylori eradication on the progression of precancerous lesions to metachronous cancer after endoscopic resection of early gastric cancer (EGC).METHODS:
Patients who underwent endoscopic resection of EGC were retrospectively reviewed. Changes in precancerous lesions and development of metachronous cancer were compared according to H. pylori eradication and final infection status.RESULTS:
In total, 565 patients were followed for over 5 years after endoscopic resection of EGC. The grade of atrophy on corpus was significantly lower in the H. pylori-eradicated group than in the persistent group during follow-up (p=0.029). In patients < 70 years of age, the cumulative incidence rate of metachronous cancer was significantly lower in the H. pylori-eradicated group than in the persistent group (p=0.018). Age was an independent risk factor for metachronous cancer development.CONCLUSIONS:
H. pylori eradication might prevent the development of metachronous cancer in patients < 70 years of age by delaying the progression of precancerous lesions after endoscopic resection of EGC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Atrofia
/
Neoplasias Gástricas
/
Incidencia
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Estudios de Seguimiento
/
Helicobacter pylori
/
Helicobacter
/
Metaplasia
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2018
Tipo del documento:
Artículo
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