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A National Study of Survival Trends and Conditional Survival in Nasopharyngeal Carcinoma: Analysis of the National Population-Based Surveillance Epidemiology and End Results Registry / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 324-334, 2018.
Artículo en Inglés | WPRIM | ID: wpr-713900
ABSTRACT

PURPOSE:

Conditional survival (CS) provides important information on survival for a period of time after diagnosis. Currently, information on CS patterns of patients with nasopharyngeal carcinoma (NPC) is lacking. We aimed to analyze survival rate over time and estimate CS for NPC patients using a national population-based registry. MATERIALS AND

METHODS:

Patients diagnosed with NPC between 1973 and 2007 with at least 5-year follow-up were identified from the Surveillance Epidemiology End Results registry. Traditional survival rates and crude CS estimateswere calculated using Kaplan-Meier analysis. Risk-adjusted survival curves were plotted from the proportional hazards model using the correct group prognosis method.

RESULTS:

For 7,713 patients analyzed, adjusted baseline 5-year overall survival improved significantly from 36.0% in patients diagnosed in 1973-1979, 41.7% in 1980-1989, 46.6% in 1990-1999, to 54.7% in 2000-2007 (p < 0.01). CS analysis demonstrated that for every additional year survived, adjusted probability of surviving the next 5 years increased from 66.7% (localized), 54.0% (regional), and 35.3% (distant) at the time of diagnosis, to 83.7% (localized), 75.0% (regional), and 62.2% (distant) for patients who had survived 5 years. Adjusted 5-year CS differed among age, sex, tumor histology, ethnicity, and stage subgroups initially, but converged with time.

CONCLUSION:

Treatment outcomes of NPC patients have greatly improved over the decades. Increases in CS become more prominent in patients with distant disease than in those with localized or regional disease as patients survive longer. CS provides more dynamic prognostic information for patients who have survived a period of time after diagnosis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Modelos de Riesgos Proporcionales / Neoplasias Nasofaríngeas / Epidemiología / Tasa de Supervivencia / Estudios de Seguimiento / Programa de VERF / Diagnóstico / Estimación de Kaplan-Meier / Métodos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico / Estudio de tamizaje Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Modelos de Riesgos Proporcionales / Neoplasias Nasofaríngeas / Epidemiología / Tasa de Supervivencia / Estudios de Seguimiento / Programa de VERF / Diagnóstico / Estimación de Kaplan-Meier / Métodos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico / Estudio de tamizaje Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2018 Tipo del documento: Artículo