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TORCH (toxoplasmosis, rubella, cytomegalovirus, and herpes simplex virus) screening of small for gestational age and intrauterine growth restricted neonates: efficacy study in a single institute in Korea / 소아과
Korean Journal of Pediatrics ; : 114-120, 2018.
Artículo en Inglés | WPRIM | ID: wpr-714074
ABSTRACT

PURPOSE:

Routine screening for toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (TORCH) in intrauterine growth restriction (IUGR) and small for gestational age (SGA) neonates has become a common practice. However, the incidence of TORCH varies across countries, and the cost of TORCH testing may be disadvantageous compared to disease-specific screening. To evaluate the efficacy of TORCH screening, the medical charts of IUGR or SGA neonates born in a single institution in Bucheon, Korea from 2011 to 2015 were reviewed.

METHODS:

The clinical data of the 126 IUGR or SGA neonates were gathered, including gestational age, Apgar scores, neonatal sonographic findings, chromosome study, morbidities, developmental follow-up, and growth catch-up. Maternal factors including underlying maternal disease and fetal sonography were collected, and placental findings were recorded when available. TORCH screening was done using serum IgM, CMV urine culture, quantification of CMV DNA with real-time polymerase chain reaction, and rapid plasma reagin qualitative test for syphilis. Tests were repeated only for those with positive results.

RESULTS:

Of the 119 TORCH screenings, only one was positive for toxoplasmosis IgM. This result was deemed false positive due to negative IgM on repeated testing and the absence of clinical symptoms.

CONCLUSION:

Considering the incidence and risk of TORCH in Korea, the financial burden of TORCH screening, and the single positive TORCH finding in our study, we suggest disease-specific screening based on maternal history and the clinical symptoms of the neonate. Regarding CMV, which may present asymptomatically, universal screening may be appropriate upon cost-benefit analysis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Rubéola (Sarampión Alemán) / ADN / Inmunoglobulina M / Sífilis / Toxoplasmosis / Tamizaje Masivo / Incidencia / Estudios de Seguimiento / Ultrasonografía Tipo de estudio: Estudio diagnóstico / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Investigación cualitativa / Factores de riesgo / Estudio de tamizaje Límite: Humanos / Recién Nacido País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Pediatrics Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Rubéola (Sarampión Alemán) / ADN / Inmunoglobulina M / Sífilis / Toxoplasmosis / Tamizaje Masivo / Incidencia / Estudios de Seguimiento / Ultrasonografía Tipo de estudio: Estudio diagnóstico / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Investigación cualitativa / Factores de riesgo / Estudio de tamizaje Límite: Humanos / Recién Nacido País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Pediatrics Año: 2018 Tipo del documento: Artículo