Trough level of infliximab is useful for assessing mucosal healing in Crohn's disease: a prospective cohort study
Intestinal Research
;
: 223-232, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-714188
ABSTRACT
BACKGROUND/AIMS:
Decreased trough levels of infliximab (TLI) and antibodies to infliximab (ATI) are associated with loss of response (LOR) in Crohn's disease. Two prospective studies were conducted to determine whether TLI or ATI better correlates with LOR (Study 1), and whether TLI could become a predictor of mucosal healing (MH) (Study 2).METHODS:
Study 1 was conducted in 108 patients, including those with LOR and remission to compare ATI and TLI in discriminating the 2 conditions based on receiver operating characteristic (ROC) curve analyses. Study 2 involved 35 patients who were evaluated endoscopically.RESULTS:
In Study 1, there were no differences between the 2 assays in ROC curve analyses; the TLI cutoff value for LOR was 2.6 µg/mL (sensitivity, 70.9%; specificity, 79.2%), and the ATI cutoff value was 4.9 µg/mL (sensitivity, 65.5%; specificity, 67.9%). The AUROC (area under the ROC curve) of TLI was greater than that of ATI. AUROC was useful for discriminating between the 2 conditions. In Study 2, the TLI was significantly higher in the colonic MH group than in the non-MH group (2.7 µg/mL vs. 0.5 µg/mL, P=0.032).CONCLUSIONS:
TLI is better than ATI for clinically diagnosing LOR, and a correlation was observed between TLI and colonic MH.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Crohn
/
Estudios Prospectivos
/
Curva ROC
/
Estudios de Cohortes
/
Sensibilidad y Especificidad
/
Colon
/
Infliximab
/
Anticuerpos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Intestinal Research
Año:
2018
Tipo del documento:
Artículo
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