Underregistration and Underreporting of Stem Cell Clinical Trials in Neurological Disorders
Journal of Clinical Neurology
;
: 215-224, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-714332
ABSTRACT
BACKGROUND AND PURPOSE:
Research on stem cells (SC) is growing rapidly in neurology, but clinical applications of SC for neurological disorders remain to be proven effective and safe. Human clinical trials need to be registered in registries in order to reduce publication bias and selective reporting.METHODS:
We searched three databases—clinicaltrials.gov, the Clinical Research Information System (CRIS), and PubMed—for neurologically relevant SC-based human trials and articles in Korea. The registration of trials, posting and publication of results, and registration of published SC articles were examined.RESULTS:
There were 17 completed trials registered at clinicaltrials.gov and the CRIS website, with results articles having been published for 5 of them. Our study found 16 publications, of which 1 was a review article, 1 was a protocol article, and 8 contained registered trial information.CONCLUSIONS:
Many registered SC trials related to neurological disorders are not reported, while many SC-related publications are not registered in a public registry. These results support the presence of biased reporting and publication bias in SC trials related to neurological disorders in Korea.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Publicaciones
/
Células Madre
/
Sistemas de Información
/
Sesgo
/
Sistema de Registros
/
Sesgo de Publicación
/
Corea (Geográfico)
/
Enfermedades del Sistema Nervioso
/
Neurología
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Clinical Neurology
Año:
2018
Tipo del documento:
Artículo
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