Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats / 소아과
Korean Journal of Pediatrics
;
: 150-155, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-714566
ABSTRACT
PURPOSE:
Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.METHODS:
We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry.RESULTS:
Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress.CONCLUSION:
Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
/
Convulsiones
/
Espasmo
/
Espasmos Infantiles
/
Inmunohistoquímica
/
N-Metilaspartato
/
Epilepsia
/
Ácido gamma-Aminobutírico
/
Glutamato Descarboxilasa
/
Inmovilización
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Pediatrics
Año:
2018
Tipo del documento:
Artículo
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