Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats / 소아과
Korean Journal of Pediatrics
; : 150-155, 2018.
Article
en En
| WPRIM
| ID: wpr-714566
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms. METHODS: We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry. RESULTS: Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress. CONCLUSION: Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Convulsiones
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Espasmo
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Espasmos Infantiles
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Inmunohistoquímica
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N-Metilaspartato
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Epilepsia
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Ácido gamma-Aminobutírico
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Glutamato Descarboxilasa
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Inmovilización
Límite:
Animals
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Humans
Idioma:
En
Revista:
Korean Journal of Pediatrics
Año:
2018
Tipo del documento:
Article