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Impact of presence of antiphospholipid antibodies on in vitro fertilization outcome
Obstetrics & Gynecology Science ; : 359-366, 2018.
Artículo en Inglés | WPRIM | ID: wpr-714707
ABSTRACT

OBJECTIVE:

To investigate prevalence of antiphospholipid antibody (APA) in Korean infertile women undergoing the first in vitro fertilization (IVF) treatment and to evaluate the influence of APA on the subsequent IVF outcomes.

METHOD:

Two hundred nineteen infertile women who destined the first IVF were prospectively enrolled in 2 infertility centers. Male factor or uterine factor infertility and women with past or current endocrine or immunologic disorders were completely excluded. Plasma concentration of lupus anticoagulant was measured by clot-based method, and anticardiolipin antibody (IgG/IgM), and anti-β2-glycoprotein 1 antibody (IgG/IgM) was measured by enzyme-linked immunosorbent assay method before starting ovarian stimulation for IVF.

RESULTS:

APA was positive in 13 women (5.9%). Lupus anticoagulant was positive in 2 women (0.9%), anticardiolipin antibody was positive in 7 women (3.2%), and anti-β2-glycoprotein 1 antibody was positive in 4 women (1.8%). In 193 women entering embryo transfer, clinical characteristics and stimulation outcomes were comparable between APA-positive (n=12) and APA-negative group (n=181). The clinical pregnancy rate (66.7% vs. 45.9%), ongoing pregnancy rate (58.3% vs. 37.0%), and miscarriage rate (12.5% vs. 19.3%) were all similar between APA-positive and APA-negative group.

CONCLUSION:

The prevalence of APA is low in Korean infertile women undergoing the first IVF cycle, and the presence of APA appears to neither decrease their first IVF success nor increase abortion rate.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inducción de la Ovulación / Plasma / Técnicas In Vitro / Ensayo de Inmunoadsorción Enzimática / Fertilización In Vitro / Aborto Espontáneo / Prevalencia / Estudios Prospectivos / Aborto Inducido / Inhibidor de Coagulación del Lupus Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Femenino / Humanos / Masculino / Embarazo Idioma: Inglés Revista: Obstetrics & Gynecology Science Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Inducción de la Ovulación / Plasma / Técnicas In Vitro / Ensayo de Inmunoadsorción Enzimática / Fertilización In Vitro / Aborto Espontáneo / Prevalencia / Estudios Prospectivos / Aborto Inducido / Inhibidor de Coagulación del Lupus Tipo de estudio: Estudio observacional / Estudio de prevalencia / Factores de riesgo Límite: Femenino / Humanos / Masculino / Embarazo Idioma: Inglés Revista: Obstetrics & Gynecology Science Año: 2018 Tipo del documento: Artículo