Your browser doesn't support javascript.
loading
Plasma CRABP2 as a Novel Biomarker in Patients with Non-Small Cell Lung Cancer
Journal of Korean Medical Science ; : e178-2018.
Artículo en Inglés | WPRIM | ID: wpr-715018
ABSTRACT

BACKGROUND:

Lung cancer is the most common cause of cancer-related mortality worldwide. We previously reported the identification of a new genetic marker, cellular retinoic acid binding protein 2 (CRABP2), in lung cancer tissues. The aim of this study was to assess plasma levels of CRABP2 from patients with non-small cell lung cancer (NSCLC).

METHODS:

Blood samples that were collected from 122 patients with NSCLC between September 2009 and September 2013 were selected for the analysis, along with samples from age- (± 5 years), sex-, and cigarette smoking history (± 10 pack-years [PY])-matched controls from the Korea Biobank Network. The control specimens were from patients who were without malignancies or pulmonary diseases. We measured plasma levels of CRABP2 using commercially available enzyme-linked immunosorbent assay kits.

RESULTS:

The mean age of the NSCLC patients was 71.8 ± 8.9 years, and the median cigarette smoking history was 32 PY (range, 0–150 PY). Plasma CRABP2 levels were significantly higher in patients with NSCLC than in the matched controls (37.63 ± 28.71 ng/mL vs. 24.09 ± 21.09 ng/mL, P < 0.001). Higher plasma CRABP2 levels were also correlated with lower survival rates in NSCLC patients (P = 0.014).

CONCLUSION:

Plasma CRABP2 levels might be a novel diagnostic and prognostic marker in NSCLC.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Tretinoina / Ensayo de Inmunoadsorción Enzimática / Biomarcadores / Fumar / Proteínas Portadoras / Marcadores Genéticos / Tasa de Supervivencia / Mortalidad / Carcinoma de Pulmón de Células no Pequeñas Tipo de estudio: Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2018 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Plasma / Tretinoina / Ensayo de Inmunoadsorción Enzimática / Biomarcadores / Fumar / Proteínas Portadoras / Marcadores Genéticos / Tasa de Supervivencia / Mortalidad / Carcinoma de Pulmón de Células no Pequeñas Tipo de estudio: Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2018 Tipo del documento: Artículo