Two combined amino acids promote sleep activity in caffeine-induced sleepless model systems
Nutrition Research and Practice
;
: 208-214, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-715246
ABSTRACT
BACKGROUND/OBJECTIVES:
The aim of this study was to evaluate the biological and sleep-promoting effects of combined γ-aminobutyric acid (GABA) and 5-hydroxytryptophan (5-HTP) using caffeine-induced sleepless fruit flies, ICR mice, and Sprague-Dawley rats. MATERIALS/METHODS:
Video-tracking analysis was applied to investigate behavioral changes of Drosophila melanogaster. Pentobarbital-induced sleep test and electroencephalogram (EEG) patterns were used for analysis of sleep latency, duration, and quantity and quality of sleep in vertebrate models.RESULTS:
Administration of combined GABA/5-HTP could significantly reverse the caffeine induced total distance of flies (P < 0.001). Also, individually administered and combined GABA/5-HTP significantly increased the total sleeping time in the caffeine-induced sleepless ICR mice (P < 0.001). In the caffeine-induced sleepless SD-rats, combined GABA/5-HTP showed significant differences in sleep quality between individual amino acid administrations (P < 0.05).CONCLUSIONS:
Taken together, we identified inhibitory effects of combined GABA/5-HTP in locomotor activity, sleep quantity and quality in caffeine-induced sleepless models, indicating that combined GABA/5-HTP may be effective in patients with insomnia by providing sufficient sleep.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vertebrados
/
Cafeína
/
5-Hidroxitriptófano
/
Ratas Sprague-Dawley
/
Dípteros
/
Drosophila melanogaster
/
Electroencefalografía
/
Frutas
/
Ácido gamma-Aminobutírico
/
Aminoácidos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Nutrition Research and Practice
Año:
2018
Tipo del documento:
Artículo
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