A new biomarker for the early diagnosis of ovarian torsion: SCUBE-1 / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 94-99, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-715306
ABSTRACT
OBJECTIVE:
Prompt diagnosis and management are essential for saving the adnexal organs from infarction in cases of ovarian torsion (OT). This study aimed to determine the diagnostic significance of signal peptide, complement C1r/C1s, Uegf, and Bmp1 (CUB), and epidermal growth factor-like domain-containing protein-1 (SCUBE-1) levels in cases of OT, an emergent ischemic condition, and the relationship of SCUBE-1 with oxidative stress parameters.METHODS:
This prospective study was conducted among 15 OT patients and 20 age- and gravidity-matched healthy women. SCUBE-1 serum concentrations were determined by using enzyme-linked immunosorbent assays. In addition, oxidative stress was evaluated by measuring the serum levels of advanced oxidation protein products (AOPP), ferric reducing ability of plasma (FRAP), and glutathione (GSH).RESULTS:
The SCUBE-1 titers were significantly higher in the patients with OT than in the controls (p=0.008). In addition, serum FRAP and GSH levels were significantly lower in the OT patients than in the controls (p 0.05). Furthermore, there were no correlations between SCUBE-1 levels and age, gravidity, parity, cyst size, and AOPP, FRAP, or GSH levels (p>0.05).CONCLUSION:
We believe that SCUBE-1 may be a promising biomarker for the early diagnosis of OT.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Paridad
/
Plasma
/
Señales de Clasificación de Proteína
/
Proteínas del Sistema Complemento
/
Ensayo de Inmunoadsorción Enzimática
/
Estudios Prospectivos
/
Estrés Oxidativo
/
Número de Embarazos
/
Diagnóstico Precoz
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Clinical and Experimental Reproductive Medicine
Año:
2018
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS