Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population
Yonsei Medical Journal
;
: 519-523, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-715389
ABSTRACT
PURPOSE:
Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS ANDMETHODS:
An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods.RESULTS:
Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis.CONCLUSION:
EBF2 gene variants can contribute to KD in the Korean population.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Modelos Logísticos
/
Exones
/
Polimorfismo de Nucleótido Simple
/
Reacción en Cadena en Tiempo Real de la Polimerasa
/
Frecuencia de los Genes
/
Inflamación
/
Síndrome Mucocutáneo Linfonodular
Tipo de estudio:
Estudio pronóstico
/
Factores de riesgo
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Yonsei Medical Journal
Año:
2018
Tipo del documento:
Artículo
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