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Prognostic Value of Baseline ¹⁸F-Fluorodeoxyglucose PET/CT in Patients with Multiple Myeloma: A Multicenter Cohort Study
Korean Journal of Radiology ; : 481-488, 2018.
Artículo en Inglés | WPRIM | ID: wpr-715443
ABSTRACT

OBJECTIVE:

We investigated the prognostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with multiple myeloma (MM). MATERIALS AND

METHODS:

Subjects were 76 patients with newly diagnosed myeloma and pretreatment with 18F-FDG PET/CT from four hospitals. The PET/CT features were evaluated and the clinical characteristics were reviewed. Prognostic factors related to poor progression-free survival (PFS) and overall survival (OS) were identified using a Cox proportional hazards regression model and a prediction scale was developed based on the identified factors.

RESULTS:

Multivariate analysis showed that the presence of 18F-FDG-avid focal bone lesions (≥ 3) was a significant and independent predictor of PFS (hazard ratio [HR] = 3.28, p = 0.007) and OS (HR = 11.78, p = 0.001). The presence of extramedullary disease on PET/CT scan was also a significant predictor of poor PFS (HR = 2.79, p = 0.006) and OS (HR = 3.89, p = 0.003). A prognostic scale was developed using these two predictors. An increase in score on the scale corresponded to a significantly increased risk of poor OS (p = 0.005). In addition, Kaplan-Meier analysis demonstrated that patient survival varied significantly according to the scale (p < 0.001 for OS and p = 0.001 for PFS).

CONCLUSION:

18F-FDG-avid focal lesions and the presence of extramedullary disease on PET/CT scan are significantly associated with poor OS in MM patients. The scale developed according to these predictors represents a potential prognostic tool for evaluation of patients with MM.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Análisis Multivariante / Estudios de Cohortes / Supervivencia sin Enfermedad / Fluorodesoxiglucosa F18 / Electrones / Estimación de Kaplan-Meier / Tomografía Computarizada por Tomografía de Emisión de Positrones / Mieloma Múltiple Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Radiology Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Análisis Multivariante / Estudios de Cohortes / Supervivencia sin Enfermedad / Fluorodesoxiglucosa F18 / Electrones / Estimación de Kaplan-Meier / Tomografía Computarizada por Tomografía de Emisión de Positrones / Mieloma Múltiple Tipo de estudio: Ensayo Clínico Controlado / Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Korean Journal of Radiology Año: 2018 Tipo del documento: Artículo