Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency / 소아과
Korean Journal of Pediatrics
;
: 425-428, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-71581
ABSTRACT
Ornithine transcarbamylase (OTC) deficiency is well known as the most common inherited disorder of the urea cycle, and 1 of the most common causes of hyperammonemia in newborns. We experienced a case of a 3-day-old boy with OTC deficiency who appeared healthy in the first 2 days of life but developed lethargy and seizure soon afterwards. His serum ammonia level was measured as >1700 microg/dL (range, 0 to 45 microg/dL). Continuous renal replacement therapy (CRRT) in the mode of continuous venovenous hemodiafiltration was immediately applied to correct the raised ammonia level. No seizure occurred after the elevated ammonia level was reduced. Therefore, CRRT should be included as 1 of the treatment modalities for newborns with inborn errors of metabolism, especially hyperammonemia. Here, we report 1 case of successful treatment of hyperammonemia by CRRT in a neonate with OTC deficiency.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ornitina
/
Ornitina Carbamoiltransferasa
/
Convulsiones
/
Urea
/
Terapia de Reemplazo Renal
/
Hemodiafiltración
/
Enfermedad por Deficiencia de Ornitina Carbamoiltransferasa
/
Hiperamonemia
/
Letargia
/
Amoníaco
Límite:
Humanos
/
Lactante
/
Recién Nacido
Idioma:
Inglés
Revista:
Korean Journal of Pediatrics
Año:
2011
Tipo del documento:
Artículo
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