Large Cell Neuroendocrine Carcinoma of the Colon With Carcinomatosis Peritonei
Annals of Coloproctology
;
: 222-225, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-716194
ABSTRACT
Colorectal large-cell neuroendocrine carcinomas (NECs) are extremely rare and have very poor prognosis compared to adenocarcinomas. A 74-year-old man presented with abdominal pain, diarrhea and hematochezia. The histopathologic report of colonoscopic biopsy performed at a local clinic was a poorly differentiated carcinoma. An abdominopelvic computed scan revealed irregularly enhanced wall thickening at the sigmoid colon with regional fat stranding and lymphnode enlargement. He underwent a laparoscopic high anterior resection with selective peritonectomy for peritoneal carcinomatosis, intraoperative peritoneal irrigation chemotherapy, and early postoperative intraperitoneal chemotherapy for 5 days. The tumor had a high proliferation rate (mitotic count > 50/10 HPFs and 90% of the Ki-67 index) and lymph-node metastases had occurred. On immunohistochemistry, the tumor cells expressed CD56 and synaptophysin. Large-cell NEC was confirmed. Systemic chemotherapy with cisplatin/etoposide was done. The patient is still alive after 3 years with no evidence of recurrence.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Recurrencia
/
Colon Sigmoide
/
Biopsia
/
Inmunohistoquímica
/
Lavado Peritoneal
/
Carcinoma
/
Adenocarcinoma
/
Dolor Abdominal
/
Sinaptofisina
Tipo de estudio:
Estudio pronóstico
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Annals of Coloproctology
Año:
2018
Tipo del documento:
Artículo
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